Face + Hand Dry Mask (TEGO® Pep 4-Even) Face + Hand Dry Mask (TEGO® Pep 4-Even)
Handlekurv

In vivo study overview conducted for claim support:


Concentration of pure Tetrapeptide-30 in all studies:

40 ppm (or 2.5% of TEGO® Pep 4-Even)

In vivo biopsy study: Reduction of melanogenesis

activation in human skin

An in vivo biopsy study was performed, in order to

prove the mitigating effect of Tetrapeptide-30 on

keratinocyte-secreted factors that are involved in

melanocyte activation via anti-inflammatory mechanisms.

Figure 2: Induction of gene expression of POMC,

Tyrosinase and different inflammation markers in punch

biopsies of human skin after 4 weeks

Following four weeks of treatment with

Tetrapeptide-30, the skin was exposed to 1.5 MED

of UV irradiation. This reduced the gene expression

of the melanogenic and inflammation markers. This

confirms the smart skin brightening mechanism of

TEGO® Pep 4-Even, which shows anti-inflammatory

activity by influencing cell-cell communication

between keratinocytes and melanocytes

In vivo efficacy study on Caucasian skin:

Lightening the skin tone on the hand

Figure 4: Reduction of yellowish skin color and age spots

on the hand by Tetrapeptide-30 in combination with

Sodium Ascorbyl Phosphate (left side: start, right side:

after 8 weeks)


To evaluate the performance of Tetrapeptide-30, the

study was performed against a vehicle containing a

Vitamin C derivative (Sodium Ascorbyl Phosphate), a

well-known tyrosinase inhibitor. The results

underlined that Tetrapeptide-30 has a skin

brightening activity that is accompanied by a


reduction of skin redness, verifying the anti-

inflammatory activity of the peptide. Additionally, a


strong fading of hyperchromatic age spots of the

skin was observed.

In vivo efficacy study on Caucasian skin:

Reduction of facial age spots


Figure 5: Reduction of facial age spots by Tetrapeptide-30

in combination with Sodium Ascorbyl Phosphate (left side:

start, right side: after 6 weeks)

Tetrapeptide-30 led to a visible fading of the

hyperchromatic spots which make it an interesting

choice for anti-aging products. In combination with

Sodium Ascorbyl Phosphate, the efficacy of the

cosmetic formulations was further optimized.

In vivo efficacy study on Asian skin: Improvement

of evenness of skin tone

Figure 6: Panelist with reduced hyperpigmentation by

Tetrapeptide-30 in combination with Sodium Ascorbyl

Phosphate (left side: start, right side: after 8 weeks)

Over the period of the study no change in


hyperpigmentation was observed for the vehicle-

group (only Sodium Ascorbyl Phosphate) whereas the


combination of SAP with Tetrapeptide-30 showed a

reduction in hyperpigmentation of about 15%. This

demonstrated that Tetrapeptide-30 is able to reduce

the major concerns of Asian skin: it lightens the skin

and improves the evenness of skin tone.

In vivo efficacy study on ethnic skin:

Improvement of evenness of skin tone

Figure 7: Panelist with reduced number of acne lesions (left

side: start, right side: after 12 weeks)

The study results revealed that Tetrapeptide-30 is

also able to reduce the major disorders of ethnic

skin: it improves the evenness and the overall

appearance of skin. Additionally, it reduces the

number of lesions caused by acne.

A detailed test summary report (technical dossier)

is available on request.

Claim Summary

TEGO® Pep 4-Even



TEGO® Pep 4-Even: Evonik Nutrition & Care GmbH, Goldschmidtstraße 100 45127 Essen, Germany